| 摘要 |
<p>The present invention relates to a novel process for preparing pyrrolidine derivatives of the formula (i): <IMAGE> characterized in that the compound of the following formula (II): <IMAGE> (wherein X is bromo or chloro) is reacted with the compound of the following formula: Cl-CO-R' (wherein R' is methoxy, ethoxy or t-butoxy) to obtain the acid anhydride of the following formula (III): <IMAGE> and the compound of formula (III) is acylated with the compound of the following formula (IV): <IMAGE> to obtain the compound of the following formula (V): <IMAGE> and the compound of formula (V) is reacted with thiourea to obtain the compound of the following formula (VI): <IMAGE> which is claimed per se, and, finally, the compound of formula (VI) is hydrolyzed to obtain the pyrrolidine derivatives of the formula (I).</p> |
