| 摘要 |
<p>A process is disclosed for the preparation of an indole of general formula (I) <CHEM> wherein R1 represents H or C1-6 alkyl or C3-6 alkenyl, R2 represents H or C1-3 alkyl, C3-6 alkenyl, aryl, ar(C1-4)alkyl or C5-7 cycloalkyl, R3 represents H or C1-3 alkyl group; R4 and R5, represent H or a C1-3 alkyl or propenyl group or together form an aralkylidene group; and Alk represents a C2-3 alkylene chain, or a physiologically acceptable salt or solvate thereof which comprises reacting an indole of general formula (II): <CHEM> (wherein X represents a leaving group) with an amine R1R2NH. The indoles of formula (I) are indicated for use in the treatment of migraine.</p> |
