| 摘要 |
<p>Benzofuranones of formula (I), their salts and isomers, are new: (R1 is H or aliphatic residue. R2 is an amino gp. disubstd. by a divalent hydrocarbyl residue. Ring A is opt. further substd.). Pref. cpds. have R1 as H or lower alkyl; R2 as amino substd. by 4-10C alkylene or alkenylene (opt. contg. a nitrogen, lower alkyl-substd. nitrogen, oxygen or sulphur atom, or fused with one or two benzo rings) and A opt. substd. by lower alkyl (opt. hydroxy or halo substd.), alkenyl, opt. branched 3- or 4-membered alkylene, alkoxy, alkylthio, alkanesulphinyl, alkanesulphonyl, hydroxy, halo, alkanoyloxy, alkanoyl and/or nitro. Starting materials and intermediates in prodn. of (I) are claimed as new cpds. in general terms but none are identified. (I) have antiinflammatory and analgesic activities, and inhibit synthesis of prostaglandins from arachidonic acid. They are useful in human and veterinary medicine and the usual daily dose (orally) for an adult is 0.1-0.6 g. Also, (I) absorb UV light selectively in the erythema-inducing region (290-320 nm) so can be used in cosmetics as sunscreening agents.</p> |
