Process for preparing methoxytrifluoromethylnaphthoic acid from dimethylnaphthalene

摘要

A multi-step process is described for preparing a methoxytrifluoromethylnaphthoic acid compound of formula <IMAGE> from 1,5-dimethylnaphthalene and for preparing novel intermediate compounds of formula <IMAGE> where X is chlorine or fluorine. Methoxytrifluoromethylnaphthoic acid is useful for preparing biologically active compounds such as naphthyl thioamide derivatives which inhibit aldose reductase activity.