| 摘要 |
<p>N-(substituted 1-oxoalkyl)-2,3-dihydro-1H-indol-2-carboxylic acids and derivatives thereof with the formula:<IMAGE>Where n is 1 or 0, R1 is H, alkyl, aryl, or aralkyl, R2 is H or alkyl, R3 is H, alkyl or aryl, R5 is OH, NH2 or alkoxy, or R4 and R3 together are -S-, X is H, alkyl, alkoxy or halogen, Y is H, alkyl or aryl, R4 is<IMAGE>Where L is O, NR7 or S, where R7 is H or alkyl, M is R8, OR8, SR8, or NR9R10, where R8 is H, alkyl, aryl, or aralkyl, and R9 and R10 each are H, alkyl or aryl, A is O, NR13 or S, R11 and R12 each are H, alkyl, aralkyl, or aryl, R13 is H or lower alkyl, m is O, 1, 2, or 3, R20 is H or aryl, and R21 is OH or alkoxy, or disulfides of compounds where R4 is -SH, or salt thereof is produced through different procedures.It is possible, for example, to proceed from the corresponding, previously unknown compounds, where the substitutes for the ring nitrogen atom are replaced with R15-HC=CR1-CO- or R4 is replaced with halogen or -NHR13, and where R5 can be replaced with a carboxyl protective group. R15 is H or alkyl.Compounds with formula I function as inhibitors for angiotensin-converting enzymes and as anti-hypertension agents.</p> |
