PROCESS FOR MANUFACTURING 3'-ACYLATED MACROLIDE ANTIBIOTICS

摘要

3"-Acylated macrolide antibiotics I [ R3 = alkynoyl (C2-C6) group ; R4 = alkanoyl (C4-C5) group; R11 = alkanoyl (C2-C3) group were prepd. The compds. II [ R1 = H, alkanoyl (C2-C3) group; R61 = alkanoyl (C2-C4) group were reacted with p-nitro benzoly halide in existence with organic t-amines, and then heated with aliphatic carboxylic anhydride. This mixt. was treated with amonia satd. ethanol, and heated in methanol to give the compds I.