| 摘要 |
<p>Compds. of the formula (I) [R = H; R1 = COC6H4O(CH2)2NR2R3; R2 = R3 =alkyl; R2R3 = (CH2)4-6, (CH2)2OC(CH2)2, etc. and their acid addn. salts were prepd. by Friedel-Crafts acylation of (I) [R = Ac, Bz, MeSO2; R1 = H followed by hydrolysis of the ester gps. Thus, HSC6H4OMe-3 was treated with BrCH2COC6H4OMe-4 to give 3- MeOC6H4SCH2COC6H4OMe-4, which was cyclized with polyphosphoric acid to give (I) [R = Me, R1 = H . Penethylation of the latter followed by esterification with MeSO2Cl gave (I) [R = MeSO2, R1= H; II . Friedel- Crafts acylation of 4g(II) with 4-Me2N(CH2)2OC6H4COCl gave 6.2g (I) [R1 = MeSO2, R1 = COC6H4O (CH2)NMe-4, III . Hydrolysis ofd III gave I [R = H . (I) are used for treating the hormone-dependent tumors.</p> |
