发明名称 |
Regulation of amyloid precursor protein expression by modification of ABC transporter expression or activity |
摘要 |
The invention relates to the discovery that expression of amyloid precursor protein is regulated by the expression of an ABC transporter. The invention therefore provides methods and compositions for modulating amyloid precursor protein expression in a brain cell, thereby preventing or inhibiting pathological beta-amyloid plaque formation in conditions such as Alzheimer's disease.
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申请公布号 |
US2002169137(A1) |
申请公布日期 |
2002.11.14 |
申请号 |
US20020072621 |
申请日期 |
2002.02.08 |
申请人 |
ACTIVE PASS PHARMACEUTICALS, INC. |
发明人 |
REINER PETER B.;CONNOP BRUCE P.;POLLARD MICHELLE |
分类号 |
A61K38/00;A61K48/00;A61P25/28;C07K14/47;C07K14/705;C12N15/12;C12Q1/68;G01N33/566;G01N33/68;(IPC1-7):A61K48/00;A61K38/17 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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