| 摘要 |
<p>Tetrahydro-β-carboline derivative of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="27" wi="68" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>Wherein R<Sup>2</Sup> is lower alkyl, and either
<UnorderedLists id="ula01" listStyle="none"><ListItem>A) R<Sup>1</Sup> is hydroxymethyl or carboxy,
<UnorderedLists id="ula02" listStyle="none"><ListItem>R<Sup>3</Sup> and R<Sup>4</Sup> are both hydrogen, and</ListItem><ListItem>X is halogen, lower alkyl, lower alkoxy, hydroxy or</ListItem><ListItem>benzyloxy; or</ListItem></UnorderedLists></ListItem><ListItem>B) R' is hydrogen, carboxy-lower alkyl or a group of the formula: -CN<Sub>2</Sub>OY,
<UnorderedLists id="ula03" listStyle="none"><ListItem>Y is lower alkyl, lower alkanoyl or an oxygen-containing</ListItem><ListItem>monocyclic heterocyclic group,</ListItem><ListItem>R<Sup>3</Sup> is hydrogen, hydroxy-lower alkyl or carboxy,</ListItem><ListItem>R" is hydrogen or hydroxy-lower alkyl, and</ListItem><ListItem>X is hydrogen,</ListItem></UnorderedLists>or salt thereof, which has excellent activities for alleviating, curing and preventing hepatic damages and is useful as a therapeutic or prophylactic agent for hepatic diseases.</ListItem></UnorderedLists></p> |
