DERIVATIVES OF CYCLOALKA[C]PYRROLCARBOXYLIC ACIDS, A PROCESS FOR THEIR PREPARATION, AGENTS CONTAINING THESE COMPOUNDS, AND THEIR USE, AND NEW CYCLOALKA[C]PYRROLCARBOXYLIC ACIDSAS INTERMEDIATES, AND A PROCESS FOR THEIR PREPARATION

摘要

of the disclosure: Compounds of the formula I < IMG > (I) in which n = 1, 2 or 3, R1 = hydrogen, optionally amino-, acylamino or benzoylamino-substituted by alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partly hydrogenated aryl, either of which can be substituted by alkyl, alkoxy or halogen, arylalkyl which can be substituted in the aryl radical as defined above, a monocyclic or bicyclic heterocyclic radical having up to 10 ring atoms of which 1 to 2 ring atoms represent sulfur or oxygen atoms, and/or of which 1 to 4 ring atoms represent nitrogen atoms, or an aminoacid side chain, R2 = hydrogen, alkyl, alkcenyl or arylalkyl, Y = hydrogen or hydroxyl, Z = hydrogen or Y and Z together = oxygen and X = alkyl, alkenyl, cycloalkyl, aryl which can be monosubstituted, disubstituted or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or indol3-yl, a process for their preparation, agents containing these compounds, their use, and intermediates and a process for their preparation. Compounds of the Formula I, and their salts, can be used to control hypertension of various etiologies .