| 摘要 |
PURPOSE:To obtain the titled pharmaceutical useful as a remedy for angina pectoris, by incorporating and copulverizing a copulverized fine powdery composition obtained from a salt, e.g. magnesium silicate or Mg2CO3, etc. with casein and nifedipine with an enteric coating agent and a plasticizer, and dry granulating the resultant mixture. CONSTITUTION:One or more selected from magnesium silicate, Mg2CO3, dried aluminum hydroxide gel, etc. are copulverized with casein and nifedipine to give a fine powdery composition, which is then incorporated with an enteric coating agent, e.g. cellulose acetate phthalate, a plasticizer, e.g. PEG, and copulverized. The resultant copulverized mixture is then dry granulated. A higher fatty acid ester e.g. sucrose ester of a fatty acid, may be further used in addition to the above-mentioned enteric coating agent and plasticizer for the above-mentioned fine powdery composition. Thus, the aimed solid nifedipine pharmaceutical having ready absorbability and sustained release property can be obtained without using an organic solvent.
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