| 摘要 |
NEW MATERIAL:The quinone derivative of formula I [A is group of formula IIor formula III (X and Y are same or different OH, methoxy or H); n is 1-5] and its salt. EXAMPLE:6-(7-Carboxy-3-methyl-2,6-octadienyl)-2,3,4-trimethoxy-5-methy lphenol. USE:It has phospholipase-inhibiting and antithrombocyte activities and is useful as an antiplatelet, antithrombotic and remedy for cardiopathy. For example, it is useful for the remedy and prevention, etc. of cerebrovascular disorder such as transient cerebroischemic fit, cerebral infarction, cerebroarteriosclerosis, etc., peripheral blood flow disorder caused by the blocking or constriction of the vessels of the limbs, such as operation of blood vessel, blood disorder, asterioscrerosis obliterans, Raynaud's disease, etc. PREPARATION:The compound of formula I can be prepared by condensing the compound of formula IV with the compound of formula V (R is H or lower alkyl) in the presence of a catalyst such as silica alumina catalyst.
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