| 摘要 |
PURPOSE:To therapeutic poultice preparation containing a specific tackifier to increase the moisture permeability of the whole preparation and to decrease the skin irritation, and containing a carboxylic acid-based nonsteroidal anti-inflammatory agent and a transcutaneous absorption promoting agent to suppress the lowering of the anti-inflammatory activity and of the transcutaneous absorption property. CONSTITUTION:A therapeutic poultice preparation having a moisture permeability of 2,000-5,000g/m<2>/24hr, especially a tape containing a non-steroidal anti-inflammatory agent having excellent transcutaneous absorption property and anti- inflammatory effect, is composed of layers of (A) an acrylic tackifier obtained by polymerizing a monomer mixture consistin of (i) 40-99wt% alkyl acrylate and/or methacrylate having 4-12C alkyl group, (ii) 1-40wt% one or more vinyl monomers selected from alkyl acrylate and methacrylate having 1-3C alkyl group, vinyl acetate and styrene, and (iii) 0-10wt% alpha,beta-unsaturated carboxylic acid, (B) a carboxylic acid-based non-steroidal anti-inflammatory agent, and (C) an agent to promote the transcutaneous absorption.
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