| 摘要 |
PURPOSE:To prepare a soft capsule agent storable for a long period without causing the reaction of the drug content with gelatin and the precipitation of the crystal, by using an modified gelatin as a base, and compounding with a hydrolyzed product of reduced starch and/or propylene glycol. CONSTITUTION:A soft capsule agent storable for a long period without causing the lowering of the solubility nor the deterioration of the appearance can be prepared by compounding (A) base material comprising a modified gelatin, preferably a gelatin wherein the amino group in the molecule is protected with acetyl group, propionyl group, benzoyl group, phthaloyl group and/or succinoyl group, more preferably the above gelatin having a bloom strength of 100-250 and a viscosity of 10-100cps (60 deg.C) with (B) hydrolyzed product of reduced starch and/or (C) propylene blycol. The weight ratio A:C is preferably 1:(1-0.2) or the amounts of the component A, the component C and water are 30-60 pts.wt., 10-40pts.wt. and 20-50pts.wt., respectively.
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