| 摘要 |
A process is described for the preparation of oral retard tablets or dragees containing as active ingredient a compound of the general formula
<CHEM>
wherein
R stands for hydrogen or -CH2-COOH,
R<1> stands for hydrogen or C1-4 alkyl,
R<2> stands for C1-4 alkyl, C2-5 alkoxycarbonyl or carbamoyl and the dotted line stands for an optionally present double bond (or an acid addition salt or quaternary ammonium salt thereof and optionally another known active ingredient) which comprises admixing 50-70 % by weight of the active ingredient by methods known per se with 4 to 8 % by weight of hydrophobic substance with high specific surface, 7 to 12 % by weight of lipoid, 8 to 12 % by weight of polyoxycompound, 4 to 9 % by weight binding agent, 0.5 to 4 % by weight of acidic stabilizer and optionally with filling agents, diluents, and lubricants and other excipients, and formulating the obtained mixture to tablets or dragees by methods known per se. |
