| 摘要 |
<p>A process for producing an indoline of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="27" wi="60" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sub>1</Sub> is a hydrogen atom, a lower alkyl group, a lower alkoxy group, a nitro group or a hydroxyl group, R<Sub>2</Sub> is a hydrogen atom, a lower alkoxy group or a nitro group, and R<Sub>3</Sub> is a hydrogen atom, a lower alkyl group or a substituted lower alkyl group, by a cyclization reaction of a 2-halogenophenethylamine of the formula:
<Chemistry id="chema02" num="0002"><Image id="ia02" he="26" wi="60" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sub>1</Sub>, R<Sub>2</Sub> and R<Sub>3</Sub> are as defined above, and X is a halogen atom, in the presence of a copper type catalyst and a dehydrohalogenating agent, characterized in that copper bis(8-hydro- xyquinolinolate) is used as the copper type catalyst, and an alkali is used as the dehydrohalogenating agent.</p> |
