| 摘要 |
<p>7-Oxabicycloheptane substituted thio prostaglandin analogs are provided having the structural formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="20" wi="61" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein p is 0 to 4; A is CH=CH, (CH<Sub>2</Sub>)<Sub>2</Sub>, or a single bond; m is 0 to 8; R is H, lower alkyl, alkali metal or tris(hydroxymethyl)-aminomethane; n is 1 to 4; n' is 0, 1 or 2; q is 1 to 12; X is
<Chemistry id="chema02" num="0002"><Image id="ia02" he="10" wi="31" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sup>2</Sup> and R<Sup>3</Sup> may be the same or different and are H or lower alkyl; t is 0 to 5; and R<Sup>1</Sup> is H, lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, and including all stereoisomers thereof.</p><p>The compounds are cardiovascular agents and antiinflammatory agents useful, for example, in the treatment of thrombolytic disease, inflammation and pain.</p> |
