发明名称 NITROIMIDAZOLE RADIOSENSITIZERS FOR HYPOXIC TUMOR CELLS ANDCOMPOSITIONS THEREOF
摘要 <p>Compounds of the formula: < IMG > (I) wherein W is a cyclic ether containing four or five carbon atoms in the ring or radicals of the formulae: < IMG > ,and R1O-CH2-CH2-O-CH2 in which n is 1 or 2; and R1 is hydrogen or -C(O)-R2 where R2 is lower alkyl, aryl, or arylalkyl; and X and Y when taken separately, are each hydrogen or an electron withdrawing group and, when taken together, form a six membered carbocyclic aromatic ring, and salts of the said compounds with acids. The compounds are useful for radiation therapy of tumor cells.</p>
申请公布号 CA1197854(A) 申请公布日期 1985.12.10
申请号 CA19830420931 申请日期 1983.02.04
申请人 RESEARCH CORPORATION 发明人 AGRAWAL, KRISHNA C.;SAKAGUCHI, MASAKAZU
分类号 C07D233/00;C07D233/91;C07D309/00;C07D405/00;C07D405/04;(IPC1-7):C07D233/91;C07D235/24 主分类号 C07D233/00
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