| 摘要 |
NEW MATERIAL:The compound of formula I {R<1> is group of formula II [A is group of formula III (n is 0-2; when n is 1, R<11> and R<12> are H, alkyl, etc.; when n is 2, two R<11> together form a double bond and R<12> is H); R<7>-R<10> are H or alkyl]; R<2> and R<4> are lower alkyl; R<3> is H, (substituted 1-10C hydrocarbon group containing 0-4 unsaturated groups, etc.; R<5> and R<6> are H, nitro, etc.} and its salt. EXAMPLE:2,6-Dimethyl-4-( 3-nitrophenyl )-5-( 2-oxo-1,3,2-dioxaphosphorinan-2-yl )-1, 4-dihydropyridine-3-carboxylate. USE:A vasodilator and hypotensor. PREPARATION:The aldehyde of formula IV is made to react with the compound of formula R<2>COCH2R<1> (e.g. acetonitrile-2-oxo-1,3,2-dioxaphosphorinane, etc.) and the compound of formula R<4>COCH2CO2R<3> (e.g. methyl acetoacetate) in the presence of ammonia, etc.
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