| 摘要 |
PURPOSE:To obtain the titled substance in few step without problems in working environment, by substituting the nitro group in an aromatic nitro compound with chlorine using chlorine gas, and reacting the resultant reaction product with a metal fluoride in the presence of a phase transfer catalyst, e.g. a quaternary phosphonium salt. CONSTITUTION:A compound expressed by formula I (X and Y are Cl, Br, F or H; R<1>-R<6> are Cl, Br, F, NO2, CN, CF3 or H) is reacted with chlorine gas in an amount of 1.0-5 times the theoretical amount in the liquid phase or vapor phase flow system at 150-350 deg.C under ordinary pressure-100kg/cm<2> for 2-30hr to substitute the nitro group with chlorine, and the resultant reaction product is then reacted with a metal fluoride, e.g. KF, RbF or CsF, in the presence of a phase transfer catalyst, e.g. tetraphenylphosphonium chloride, expressed by formula II or III (A<1>-A<4> are alkyl or aryl; B is Cl or Br) at 200-250 deg.C under 1-10kg/cm<2> for 2-30hr to afford the aimed compound expressed by formula IV. USE:A raw material for intermediates for fluorine-containing medicines and agricultural chemicals. |
