<p>Compounds (I) are provided that act as potent antagonists of the CCR2 or CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2 and CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2 -mediated diseases, CCR9 -mediated diseases, as controls in assays for the identification of CCR2 antagonists and as controls in assays for the identification of CCR9 antagonists.</p>
申请公布号
MX2009000395(A)
申请公布日期
2009.01.29
申请号
MX20090000395
申请日期
2007.07.10
申请人
CHEMOCENTRYX, INC.
发明人
UNGASHE, SOLOMON;CHARVAT, TREVOR, T.;ZENG, YIBIN;PUNNA, SREENIVAS;HU, CHENG;MELIKIAN, ANITA;NOVACK, AARON;SULLIVAN, EDWARD, J.;TAN, XUEFEI;THOMAS, WILLIAM, D.;PENNELL, ANDREW, M. K.