| 摘要 |
NEW MATERIAL:The antibody produced by using the peptide of formula Asp- Ala-Asp-Ser-Arg-Pro-Lys-Phe-Arg-Glu-Leu as an antigen. USE:An antibody to erb B protein useful as a diagnostic agent for cancer and as a carcinostatic agent. PREPARATION:The peptide of formula Asp-Ala-Asp-Ser-Arg-Pro-Lys-Phe-Arg- Glu-Leu is bonded to a proper carrier protein such as keyhole limpet hemocyanine (KLH) by conventional process, and an animal such as mouse is immunized with the bonded product by conventional process. The above antibody can be separated from the obtained antiserum by conventional process. The antibody has the following characteristics. Class, IgG; molecular weight, 150X10<3> daton; molecular absorption coefficient, E1cm<1>280nm=14.0; reactive specifically to erb B protein and EGF receptor protein. |
