发明名称 SOLUBILIZATION OF INTERFERON
摘要 PURPOSE:To prepare an interferon-containing composition soluble easily in water, by solubilizing an interferon useful as an antiviral agent, carcinostatic agent, etc. using an amino acid as the solubilizing agent. CONSTITUTION:An amino acid selected from arginine, histidine, lysine, hydroxylysine, ornithine, glutamine, gamma-aminobutyric acid, epsilon-aminocaproic acid and their salts is used as a solubilizing agent for an interferon selected from interferon-alpha, interferon-beta and interferon-gamma which is difficult to be separated and purified from the cultured product because of its slight solubility in water. The solubility of the interferon can be increased by this process. The amount of the amino acid is about 5X10<-5>-5X10<-3>mol per 1,000,000 units of the interferon. The amino acid is harmless to the living body and can be utilized as it is to the interferon preparation.
申请公布号 JPS60243028(A) 申请公布日期 1985.12.03
申请号 JP19840086972 申请日期 1984.04.28
申请人 KYOWA HAKKO KOGYO KK 发明人 KATOU YASUKI;HAYAKAWA EIJI;FURUYA KUNITOSHI;KONDOU AKIRA
分类号 C07K14/52;A61K38/21;A61K47/18;C07K1/00;C07K14/555;C07K14/56;C07K14/565;C07K14/57 主分类号 C07K14/52
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