| 摘要 |
The invention provides novel compounds of the formula <IMAGE> (I) or <IMAGE> (II) wherein R1 is hydrogen, hydroxy, alkoxy of 1 to 4 carbon atoms, benzyloxy, allyloxy, 2,3-epoxypropoxy, methoxymethoxy, ethoxymethoxy, or 2,3-dihydroxypropoxy or <IMAGE> wherein one of R5 and R6 is hydrogen or R5 and R6 are alkyl groups of 1-4 carbon atoms which may be the same or different, or the -NR5R6 group stands for a nitrogen containing 5 to 7 membered heterocyclic radical and m is 1 or 2; R2 is an alkyl of 1 to 4 carbon atoms or <IMAGE> wherein R7 has the same meanings as R1 except that R7 and R1 cannot simultaneously be the same; R3 is an alkyl of 2 to 4 carbon atoms, cyclopentyl or hydroxy-cyclopentyl; R4 is hydrogen or hydroxy; and n is 0 to 3, provided that when R4 is hydrogen, then R2 and R3 are not simultaneously lower alkyl containing up to 4 carbon atoms, and their non-toxic pharmaceutically acceptable acid addition salts and esters and mixtures thereof. Processes for the preparation of these compounds are described, as are novel pharmaceutical compositions of the compounds or their salts. The compounds and their non-toxic salts exhibit valuable pharmacological properties as estrogenic, anti-estrogenic, progestanic and anti-tumor activity. Certain compounds of the group are useful as chemical intermediates for the preparation of pharmaceutically active compounds of the invention.
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