| 摘要 |
PURPOSE:To prepare the titled external drug having excellent transcutaneous absorption, by dissolving or dispersing nicardipine hydrochloride useful as a vasodilator in a liquid mixture composed of a medium fatty acid glyceride, a propylene glycol and a urea compound, and forming the solution, etc. to an externally applicable drug. CONSTITUTION:The objective drug having the form suitable for external application can be prepared by dissolving or dispersing nicardipine hydrochloride in a liquid mixture obtained by compounding 1-15w/w% medium-chain fatty acid glyceride (e.g. monoglyceride or diglyceride of a 6-12C fatty acid), 1-15w/w% propylene glycol and 1-10w/w% urea compound (e.g. urea, ethylurea, etc.) preferably in an external drug. The solubility of nicardipine hydrochloride in individual medium-chain fatty acid glyceride, propylene glycol and urea compound is low; however, it can be increased, and the preparation and the transcutaneous absorption of the external drug can be improved by the use of the mixture of the above solvents.
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