| 摘要 |
NEW MATERIAL:A compound of formula I (R<1> is alkyl, alkylcarbamoyl; R<2> is H, hydroxyl or substituted hydroxyl, acyclic or cyclic amino which may be substituted; R<3> is bond, substituted or unsubstituted alkylene; R<4> is H, alkyl, aralkyl; X, Y are O, S which may be substituted, where in case that Y is NH, Y can form a ring together with X or R<4>; Z is optionally substituted NH or N- containing heterocyclic ring) and its salt. EXAMPLE:2-O-Acetyl-3-O-[N-acetyl-N-( 2'-trimethylammonioethyl )]carbamoyl-1-O- octadecylglycerol iodide. USE:In has an action of inhibiting PAF and effectively used as a preventive or remedy for a variety of circulation disorders and allergic diseases and as an antitumor. PREPARATION:The reaction of a compound of formula II (Q1 is group readily replaceable with N with an amine which may be substituted or an N-containing heterocyclic compound gives the compound of formula I. |
