| 摘要 |
<p>N-(2-Hydroxyethyl) 3-pyridine carboxamide nitrate ester of formula (I) is made by (a) reacting nicotinamide with ethanolamine hydrochloride at 110-125 deg.C for 15-30 mins.; (b) sepg. the ammonium chloride formed; (c) adding chloroform and removing the solvent under reduced pressure, leaving crude N-(2-hydroxyethyl) nicotinamide; (d) adding this slowly to fuming nitric acid at -10 deg.C, to form the nitrate ester; and (e) ppting. with ether, dissolving in Na2CO3 soln. and extraction with ethyl acetate to give (I).</p> |
