摘要 |
<p>1-Aryl 2-(piperazin-1-yl) methyl ketones and their acid addn. salts, of formula (I), in which R1 to R4 can be various gps., are prepd. by (a) reacting a phenacyl deriv. of formula (II) in which X is a nucleophobic gp., with ammonia or other reagent to introduce an amino gp., and (b) treatment with a cpd. of formula (not given) (III) in which Z is a nucleophobic gp.</p> |