| 摘要 |
<p>Compounds of the formula (I): …<CHEM>… and salts thereof are described, wherein R<1> and R<2> are a variety of substituents or are joined to form a ring; n is 1 to 6; Z is 1,3-phenylene, 1,4-phenylene, 2,4-pyridyl (wherein the R<1>R<2>N(CH2)n group is in the 4-position); m is zero or one; Y is oxygen, sulphur or methylene; p is two, three or four; and R<3> is hydrogen, C1-6alkyl or aryl(C1-6)alkyl and R<4> is hydrogen or C1-6alkyl; or R<3> and R<4> together with the carbon atoms to which they are attached form a benzene ring optionally substituted by C1-6alkyl. Processes for their preparation and intermediates therefor are described, as are pharmaceutical compositions containing them and their use as histamine H2-antagonists.</p> |
