摘要 |
<p>A 1,4-dihydropyridine derivative of the formula <IMAGE> in which R and R1 each independently is hydrogen, C1-C4-alkyl, C1 to C12-alkoxy, C1-C4-halogenoalkoxy, halogen, nitro, trifluoromethyl, <IMAGE> <IMAGE> X is oxygen or sulphur, R4 and R5 each independently is hydrogen, C1-C4-alkyl, C1-C6-alkoxy, halogen, trifluoromethyl, amino or nitro, and R2 and R3 each independently is hydrogen, a C1-C10-alkyl, C2-C10-alkenyl or C3-C10-alkinyl radical which is optionally substituted by halogen, hydroxyl, C1-C4-alkoxy, amino, mono- and di-C1-C4-alkylamino, carbo-C1-C6-alkoxy and/or nitro, a C3 to C6-membered cycloalkyl radical, a phenyl radical which is optionally substituted by C1-C4-alkyl, C1-C6-alkoxy, halogen, amino and/or nitro, or a phenyl-C1-C3-alkyl radical, or a carbohydrate radical which is optionally bonded via a C1-C8-alkyl chain to the amide nitrogen atom or a pharmaceutically acceptable acid addition salt thereof, which improves the contractility of the heart, raises the blood pressure, lowers the blood sugar, reduces the swelling of mucous membranes and affects the salt and fluid balances of a patient.</p> |