INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
摘要
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
申请公布号
EP3027625(A1)
申请公布日期
2016.06.08
申请号
EP20140831878
申请日期
2014.07.28
申请人
MERCK SHARP & DOHME CORP.
发明人
TANG, HAIFENG;PIO, BARBARA;JIANG, JINLONG;PASTERNAK, ALEXANDER;DONG, SHUZHI;FERGUSON, RONALD DALE, II;GUO, ZACK ZHIQIANG;CHOBANIAN, HARRY;FRIE, JESSICA;GUO, YAN;WU, ZHICAI;YU, YANG;WANG, MING