| 摘要 |
PURPOSE:To provide a peripheral circulation promoting agent for external use, containing a specific ascorbic acid derivative as an active component, exhibiting dermatic blood-flow promoting effect at a low concentration, free from side effects to the skin, and effective to the maintenance of the health of the skin, hair growth, prevention of gingivitis, etc. CONSTITUTION:The objective agent contains the ascorbic acid derivative of formula (at least one of R1-4 is 1-20C alkyl, alkenyl, etc., and the others are H) as an active component. It has been found that when the compound of formula is applied topically, dermatic blood-flow can be promoted at an extremely low concentration without causing side effects such as stimulation, allergic reaction, or burning sensation of the skin, and the compound can be maintained stably for a long period. It does not influence the skin temperature, and dilates the blood vessel by the direct action to the smooth muscle of the vessel. It is applied topically for the maintenance of the health of the skin, the prevention of retroplasia, the growth and nonrishment of the hair, and the prevention of gingivitis, etc. |
