| 摘要 |
NEW MATERIAL:A 5-fluorouracil derivative of the formula (R is acyl derived from pentaenoic higher fatty acid or hexaenoic higher fatty acid). EXAMPLE:1-(5,8,11,14,17-Eicosapentaenoyloxymethyl)-5-fluorouracil. USE:Useful as a carcinostatic agent and inhibitor for blood platelet agglutination with antitumor action and low toxicity, and administered orally in the form of a capsule or tablet, etc. or parenterally in the form of a suppository, etc. PREPARATION:A pentaenoic higher fatty acid or hexaenoic higher fatty acid of the 1-hydroxymethyl derivative of 5-fluorouracil is reacted with ethyl chloroformate (ClCO2C2H5) in the presence of a base to give a solution of a mixed acid anhydride, which is then reacted with a reaction mixture obtained by reacting 5-fluorouracil with formalin in the presence of a base to afford the aimed compound of the formula.
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