| 主权项 |
1. A method of targeting a therapeutic or imaging agent to a tumor tissue of a patient, the method comprising (a) identifying a patient with a tumor tissue, wherein the patient is in need of administration of a therapeutic or imaging agent to treat or image the tumor; (b) providing a conjugate of the therapeutic or imaging agent and a polysaccharide preparation; and (c) administering the conjugate to the patient, wherein the polysaccharide preparation targets the conjugate to the tumor tissue, and wherein the polysaccharide preparation has the following characteristics:
a weight average chain molecular weight between 3,500 and 8,000 Da; anti-Xa activity and anti-IIa activity each less than 50 IU/mg; and greater than 5% and less than 50% glycol split uronic acid residues; and wherein the polysaccharide preparation comprises polysaccharides of the Formula I:
[Uw—Hx,y,z]m˜[UG—Hx,y,z]n (I) wherein each occurrence of U indicates a uronic acid residue and each occurrence of H indicates a hexosamine residue; wherein m and n are integers such that m=4-16, and n=1-4; each of w, x, y and z can independently be the same or different for each occurrence of [Uw—Hx,y,z] and each of x, y and z can independently be the same or different for each occurrence of [UG—Hx,y,z], wherein w=-2OS or -2OH; x=-NS or -NAc; y=-3OS or -3OH; z=-6OS or -6OH; andwherein the symbol ˜ indicates that the units marked m and n are distributed along the polysaccharide chain and are not necessarily in sequence to thereby target the agent to the tumor tissue. |
