发明名称 |
MAMMALIAN MONOCLONAL ANTIBODIES AGAINST ENDOTOXIN OF GRAMNEGATIVE BACTERIA |
摘要 |
Mammalian monoclonal anti-LPS antibodies that react with regions of lipopolysaccharide which are common to the lipopolysaccharide molecules of gram-negative bacteria of different genera are described along with diagnostic and therapeutic uses of the anti-LPS antibodies. The monoclonal anti-LPS antibodies react with gram-negative bacteria across different genera, reacting with regions of the lipid A and/or the core of gram-negative bacterial endotoxin which are shared by virtually all types of gram-negative bacteria. The anti-LPS antibodies protect mice against the lethal effect from gram-negative bacterial infection and neutralize the lethal effect of the endotoxin of gram-negative bacteria in vivo. Also disclosed are immortal antibody-producing cells such as mammalian hybridoma cell lines which generate the monoclonal anti-LPS antibodies. The mammalian monoclonal anti-LPS antibodies are useful in a number of diagnostic and therapeutic applications, including methods for the detection of gram-negative bacteria or endotoxin of gram-negative bacteria, therapy of gram-negative bacterial infection and endotoxin shock in mammals and prophylaxis against bacterial infection in mammals. |
申请公布号 |
ZA8407944(B) |
申请公布日期 |
1985.11.27 |
申请号 |
ZA19840007944 |
申请日期 |
1984.10.11 |
申请人 |
CENTOCOR, INC. |
发明人 |
WARREN C. BOGARD, JR.;PATRICK C. KUNG |
分类号 |
G01N33/569;A61K38/00;A61K39/00;A61K39/395;A61K49/16;C07K14/005;C07K14/195;C07K16/00;C07K16/12;C07K19/00;C12N5/22;C12N15/02;C12P21/08;C12Q1/00;C12Q1/04;C12R1/91;G01N33/577 |
主分类号 |
G01N33/569 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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