发明名称 |
THIOL REACTIVE LIPOSOMES |
摘要 |
<p>THIOL REACTIVE LIPOSOMES Liposomes are provided which have a plurality of thiol reactive groups extending outward of the liposomal bilayer. The liposomes form stable covalent bonds with ligands having thiol groups, such as Fab' fragments. Particularly preferred liposomes include maleimide moieties as the thiol reactive groups. The thiol reactive liposomes are usefully employed in agglutination assays, such as blood typing and binding inhibitions, and targeting to specific cells.</p> |
申请公布号 |
CA1197190(A) |
申请公布日期 |
1985.11.26 |
申请号 |
CA19820417106 |
申请日期 |
1982.12.06 |
申请人 |
REGENTS OF THE UNIVERSITY OF CALIFORNIA (THE) |
发明人 |
MARTIN, FRANK J.;PAPAHADJOPOULOS, DEMETRIOS P.;HUBBELL, WAYNE L. |
分类号 |
A61K9/127;G01N33/532;G01N33/563;(IPC1-7):A61K9/50;A61K39/44;B01J13/02 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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