| 摘要 |
<p>Pharmaceutically active 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides having the general formula: < IMG > (I) wherein R is phenyl, aryl substituted with halogen or with C1-C6 alkyl groups, 2, 3 or 4pyridyl or pyridyl substituted with halogen or with C1-C6 alkyl groups, 5-methyl-isoxazolyl or 2-thiazolyl, are prepared by reacting an alkyl 4hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide of the formula: < IMG > in which R1 is a C1-C6 alkyl, with a magnesium derivative of the formula: R-NH-Mg-X in which X is halogen and R has the aforesaid meanings, in an inert solvent at a temperature between about 0.degree.C and about 130.degree.C to form an intermediate product which is thereafter hydrolysed in an acid medium to provide the desired compound of the formula (I). The compounds of formula (I) have analgesic and antiinflammatory properties.</p> |
