| 摘要 |
NEW MATERIAL:The compound of formula I [R<1> and R<2> are H, alkyl, cycloalkyl, alkenyl, hydroxyl, etc.; R<1> and R<2> may together with N form a heterocyclic group; A is alkenylene; R<3> is H or alkyl; R<4> is (substituted) aryl or heterocyclic group; p is 1-3; X and Y are O or S; q is 2-4; Z is alkylene]. EXAMPLE:N-( 2-hydroxy-2-phenylethyl )-N'-{2-[[5-[3- (1-pyrrolidinyl)-1-propenyl]-2- thienyl]methylthio]ethyl}-2-nitro-1,1-ethenediamine. USE:An antiulcer agent. It has excellent effect to suppress the secretion of gastric acid, exhibits its effect at a low dose, and has high safety. PREPARATION:The compound of formula I can be prepared by reacting the compound of formula II with the compound of formula III (Q and Q' are eliminable group), and reacting the product with the compound of formula V.
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