发明名称 |
COMPOSITIONS AND METHODS OF USING TYROSINE KINASE INHIBITORS |
摘要 |
The present invention provides compositions and methods of inhibiting tyrosine phosphorylation. In one aspect, a composition includes comprising a low-dosage tyrosine kinase inhibitor, where the low-dosage tyrosine kinase inhibitor decreases tyrosine phosphorylation. In another aspect, a method is described for treating cardiovascular disease or condition associated with a RASopathy having aberrant protein tyrosine phosphorylation. Methods for treating congenital heart disease associated with Noonan or Noonan syndrome with multiple lentigines and decreasing aberrant levels of Protein Zero-Related (PZR) tyrosyl phosphorylation are also described. |
申请公布号 |
WO2016123086(A1) |
申请公布日期 |
2016.08.04 |
申请号 |
WO2016US14882 |
申请日期 |
2016.01.26 |
申请人 |
YALE UNIVERSITY |
发明人 |
BENNETT, ANTON;YI, JAE-SUNG |
分类号 |
A61K31/00;A61K31/497;A61K45/06 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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