| 摘要 |
PURPOSE:To obtain the titled compound useful as an intermediate for indoles in high yield and purity under ordinary pressure conditions, by cyclizing a 2-halogenophenethylamine in the presence of a specific copper based catalyst and an alkali as a dehydrohalogenating agent. CONSTITUTION:A 2-halogenpophenethylamine of formula I [R1 is H, lower alkyl, lower alkoxyl or nitro; R2 is H, lower alkoxyl or nitro; R3 is H, (substituted) lower alkyl; X is halogen] is reacted in the presence of copper quinolinate catalyst and an alkali as a dehydrohalogenating agent at the refluxing temperature of the reaction mixture under ordinary pressure preferably for 1-20hr to afford the aimed compound of formula II. EFFECT:The use of the alkali provides easy isolation of the indoline without affecting waste water. The copper quinolinate can be recovered by the conventional method for reuse. USE:An intermediate for indoles useful as a raw material for agricultural chemicals, medicines, perfumes, dyes, etc.
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