Griseofulvin derivatives

摘要

The present invention relates to compounds of the following general formula (I), or to a pharmaceutically acceptable salt thereof, as well as to the uses thereof as a drug, in particular for treating cancerous or precancerous hyperproliferative conditions, and to the pharmaceutical compositions containing same.;

主权项

1. A compound of following formula (I): or a pharmaceutically acceptable salt thereof, where: represents a single or double bond; —Y is C═O, C═S, CH—OR1, CHN3, CHNR2R3, C═N—OR4, C═N—NR5R6, Z is a —S(O)R7 or —S(O)2R7 group, and X is a CH—R8 group when represents a single bond, or C—R8 when represents a double bond; with: R1 to R5 each independently representing a hydrogen atom or a (C1-C6)alkyl, aryl, (C1-C6)alkyl-aryl, aryl-(C1-C6)alkyl or 5- or 6-membered heterocycle group; R6 representing a hydrogen atom or a (C1-C6)alkyl, aryl, (C1-C6)alkyl-aryl, aryl-(C1-C6)alkyl, C(O)NH2, C(S)NH2 or 5- or 6-membered heterocycle group; R7 representing a (C1-C6)alkyl, aryl, (C1-C6)alkyl-aryl, aryl-(C1-C6)alkyl or 5- or 6-membered heterocycle group; R8 representing —R11, —NHR11, —CH2—NHR11, —CH2—NH—C(O)—R11, —NH—CH2—R11, —NH—NH—R11, —NH—C(O)—R11, —NH—C(O)—CH2—R11, —NH—CH2—C(O)—R11, —NH—CH2—C(O)—O—R11, —NH—CH2—C(O)—NH—R11, —NH—SO2—R11, —S(O)—R11, —SO2—R11, —S(O)—CH2—R11, —SO2—CH2—R11 or —NR12R13; R11 representing a hydrogen atom or a (C1-C6)alkyl, carbocycle, heterocycle, biaryl, carbocycle-(C1-C6)alkyl or heterocycle-(C1-C6)alkyl group, optionally substituted; and R12 and R13 together forming, with their nitrogen atom carrier, a heterocycle optionally substituted with —R11, —OR11 or —NHR11.