| 摘要 |
<p>2,4-Disubstituted thiazole compounds of the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="22" wi="71" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>or a pharmaceutically acceptable acid addition salt thereof wherein
<UnorderedLists id="ula01" listStyle="none"><ListItem>X is NH and Y is CH or N, or</ListItem><ListItem>X is S and Y is CH;</ListItem><ListItem>R<Sup>1</Sup> is certain straight or branched chain alkyl groups, (R<Sup>3</Sup>)<Sub>2</Sub>C<Sub>6</Sub>H<Sub>3</Sub>, or (R<Sub>3</Sub>)Ar(CH<Sub>2</Sub>)<Sub>n</Sub> where n is an integer from 1 to 4, R<Sup>3</Sup> is H or certain substituent groups and Ar is phenylene, naphthalene or the residue of certain heteroaromatic groups;</ListItem><ListItem>R<Sup>2</Sup> is H or (Ci-C<Sub>4</Sub>)alkyl; or</ListItem><ListItem>R1 and R<Sup>2</Sup> taken together with the nitrogen atom to which they are attached form certain heterocyclic groups; and</ListItem><ListItem>R<Sup>4</Sup> is H, (C<Sub>1</Sub>-C<Sub>5</Sub>)alkyl, NH<Sub>2</Sub> or CH<Sub>2</Sub>0H; a method for their use in treatment of gastric ulcers in mammals and pharmaceutical compositions containing said compounds.</ListItem></UnorderedLists></p> |
