| 摘要 |
7-Oxabicycloheptane substituted oxo prostaglandin analogs are provided having the structural formula <IMAGE> wherein R is hydrogen, lower alkyl, alkali metal or tris(hydroxymethyl)aminomethane, R1 is hydrogen, lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, A is -CH=CH- or -(CH2)2-, y is 0 to 4, m is 0 to 8, and n is 1 to 4, p is 1 to 12 and q is 0 to 5, and including all stereoisomers thereof. The compounds are antiinflammatory agents useful, for example, in the treatment of inflammatory diseases and analgesic agents as well as cardiovascular agents useful, for example, in the treatment of thrombolytic disease. |
