5-(Straight chain 3-12 carbon alkoxy)-8-quinolinamines and their use for treatment of malaria

摘要

Improved means for the chemotherapy of malaria have been achieved with 5-alkoxy-primaquine analogues having the formula: <IMAGE> wherein R4 represents hydrogen or a methyl grouping, and R represents an alkyl group containing 3 to 12 carbon atoms and pharmaceutically acceptable salts thereof, wherein the salt-forming acid may be organic or inorganic in nature. These primaquine-related compounds afford improvement in the chemotherapy of malaria by exerting plasmodicidal action on malaria parasites which may be present in either the blood, formed tissues, or blood and formed tissues of the mammalian host. Such broad and practical spectrum of effectiveness distinguishes the said primaquine analogues, which may be administered parenterally or perorally to infected animals.