发明名称 |
Flowable collagen-based hemostat and methods of use |
摘要 |
The invention relates to hemostatic compositions and methods for promoting hemostasis. The invention also relates to hemostatic compositions and methods for promoting wound healing. In various embodiments, the hemostatic compositions comprise crosslinkable collagen molecules having a porosity controlled by the ratio of weight percent collagen solids to weight percent crosslinker when crosslinking the collagen. In other embodiments, the hemostatic compositions comprise crosslinkable collagen molecules having a porosity controlled by the temperature and rate of freezing when drying the composition during fabrication. In some embodiments, the compositions contain additional agents, including biological agents. |
申请公布号 |
US9447169(B2) |
申请公布日期 |
2016.09.20 |
申请号 |
US201213411324 |
申请日期 |
2012.03.02 |
申请人 |
Orthovita, Inc. |
发明人 |
Darmoc Marissa M.;Brown Lauren S.;Raynor Jenny E.;Chou Alice;Cohen Abigail |
分类号 |
A61K38/46;C07K14/78;A61K38/39;A61K38/48 |
主分类号 |
A61K38/46 |
代理机构 |
Lerner, David, Littenberg, Krumholz & Mentlik, LLP |
代理人 |
Lerner, David, Littenberg, Krumholz & Mentlik, LLP |
主权项 |
1. A hemostatic composition consisting essentially of crosslinked collagen scaffold reconstituted in a physiologically acceptable liquid vehicle,
wherein the composition does not contain thrombin; wherein the composition is flowable and has no residual amount of a crosslinker; wherein concentration of the crosslinked collagen is from 50-250 mg/mL; wherein the crosslinked collagen scaffold, prior to reconstitution, has a porosity greater than 50% and a surface area of between 0.5 to 30 m2/g; and wherein the composition has a percent swelling of between 0% to 20% within 10 minutes. |
地址 |
Malvern PA US |