UN PROCEDIMIENTO PARA PREPARAR AMINAS AROMATICAS SUSTITUIDAS CON CIANOALQUILO

摘要

The present invention provides a process for preparing compounds of formula (5): NH2-AX-CH2NH2 (5) which are useful as intermediates in the preparation of compounds which are histamine H1 -antagonists. In formula (5) A is a 5-membered heterocyclic aromatic group containing up to three hetero-atoms of which no more than one can be oxygen or sulphur and from one to three can be nitrogen; a 6-membered monocyclic aromatic group optionally containing up to three nitrogen hetero-atoms or a 9- or 10-membered bicyclic aromatic group optionally containing up to four hetero-atoms, of which no more than one can be oxygen or sulphur and from one to four can be nitrogen, the group A being optionally substituted with one or more groups which are inert under the reaction conditions; X is a C1-5 alkylene group or a C2-5 alkenyle group; which comprises (a) reacting a compound of formula (6): NO2-AX-CN (6) where A and X are as defined with reference to formula (5) with hydrazine in the presence of a transition metal catalyst to form a compound of formula (7): NH2-AX-CN (7) where A and X are as defined with reference to formula (5) and thereafter (b) reacting the compound of formula (7) so obtained with more hydrazine and Raney nickel.