| 摘要 |
<p>New thiazole derivatives for the formula: …<CHEM>… wherein… R<1> is lower alkyl, carboxy, a derivative of carboxy, hydroxymethyl, halomethyl, lower alkylthiomethyl, hydroxyiminomethyl or alkenyl which may be substituted with lower alkoxycarbonyl, pyridyl or cyano.… R<2> is hydrogen, hydroxy, lower alkyl, pyridyl, amino, lower alkylamino, pyridylamino, arylamino, acylamino, N-(lower)alkylN-acylamino, guanidino optionally substituted with dimethylaminomethylene, or ar(lower) alkylamino optionally substituted with lower alkoxy,… R<3> is lower alkyl, halo(lower)alkyl or N-containing unsaturated heterocyclic group which may be substitued with halogen, lower alkyl, lower alkoxy, carboxy, a derivative of carboxy, hydroxy, pyridyl, amino, lower alkylamino, pyridylamino, arylamino, acylamino, N-(lower)alkyl-N-acylamino, guanidino, N-oxide or ar(lower)alkylamino optionally substituted with lower alkoxy,… Q is -CO-, and… n is an integer of 0 or 1,… provided that when both of R<1> and R<3> are lower alkyl then n is an integer of 1 and R<2> is lower alkyl, pyridyl, amino lower alkylamino, pyridylamino, arylamino, acylamino, N-(lower)alkyl-N-acylamino, guanidino optionally substituted with dimethylaminomethylene, or ar(lower) alkylamino optionally substituted with lower alkoxy, and when R<1> is lower alkyl and R<3> is halo(lower)alkyl then n is an integer of 1, and pharmaceutically acceptable salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same. …<??>These derivatives and pharmaceutically acceptable salts thereof are useful as cardiotonic agents and anti-ulcer agents.</p> |
