发明名称 |
CONTROLLED ABSORPTION PHARMACEUTICAL COMPOSITION |
摘要 |
A sustained absorption propranolol-containing pellet for oral administration comprises a core of propranolol or a pharmaceutically acceptable salt thereof and an organic acid embedded in a polymeric material in a multi-layer arrangement and an outer membrane which permits release of the propranolol at a controlled rate in an aqueous medium. The pellet has a dissolution rate in vitro in an aqueous medium, which when measured in a basket assembly according to U.S. Pharmacopoeia XX at 37 DEG C. and 75 r.p.m., is not more than 15% of the total propranol after 2 hours of measurement in a buffer solution at pH 7.5. Not more than 30% of the total propranolol is released after a total of 4 hours of measurement and not more than 63% of the total propranolol is released after a total of 6 hours. |
申请公布号 |
PH18946(A) |
申请公布日期 |
1985.11.14 |
申请号 |
PH20020000305 |
申请日期 |
1984.04.05 |
申请人 |
ELAN CORPORATION PLC |
发明人 |
DONALD EUGENE PANOZ;EDWARD JAMES GEOGHEGAN |
分类号 |
A61K9/26;A61K9/50;A61K31/135;A61K31/138;A61K31/19;A61P9/00 |
主分类号 |
A61K9/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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