NOVEL 4(1H)-PYRIMIDONE DERIVATIVE AND ITS PREPARATION

摘要

NEW MATERIAL:A 4(1H)-pyrimidone derivative shown by the formula I (R<1> is 1-10C alkyl; R<2> is lower alkyl; n is 2-4) or its acid addition salt. EXAMPLE:5-Heptyl-6-methyl-2-{ 3-[ m-(piperidinomethyl)phenoxy ]propylamine }- 4(1H)-pyrimidone. USE:An inhibitor against secretion of acid in the stomach. Having both histamine H2 acceptorantagonism and protecting action on stomach mucosa. PREPARATION:For example, a piperidinomethylphenoxyalkylamine shown by the formula II is reacted with a 2-nitroamino or 2-lower alkylthio-4(1H)-pyrimidone derivative shown by the formula III, to give a compound shown by the formula I.