| 摘要 |
<p>Novel compounds of the formula: < IMG > wherein R1 is pyridyl, R2 is phenyl, thienyl, furyl, naphthyl, benzothienyl or pyridyl, any of which may be substituted by lower alkoxy, lower alkyl, halogen trifluoromethyl, lower alkenyl or methylenedioxy, R3 is hydrogen or lower alkyl, and n is an integer of 0 to 6, Y is sulphur, methylene or a group of the formula: < IMG > wherein R4 is hydrogen or acetyl, and m is 0 or 1, and their pharmaceutically acceptable salts and acid addition salts are disclosed which inhibit biosynthesis of thromboxane A2(TXA2) and accelerate the productivity of prostaglandin I2(PGI2), and can be administered to mammals for the prophylaxis or therapy of thrombosis caused by platelet aggregation or ischemic diseases caused by vasospasms in cardiac, cerebral and peripheral circulatory system (e.g. cardiac infarction, apoplexy, infarct of blood vessels in kidney, lung and other organs, pectic ulcer, etc.).</p> |
